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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: J Expo Sci Environ Epidemiol. 2021 Feb 18;31(5):900–912. doi: 10.1038/s41370-021-00306-8

Table 2.

Differential miRNA expression of a priori miRNAs by fire type exposure: separate models adjusted for age, BMI, ethnicity, batch effects.

miRNA Incumbents vs new recruitsa New recruits (follow-up vs baseline measurement)b
Employment duration Fire-hours Fire-runs Most recent firec
All fires FC 95% CI FC 95% CI FC 95% CI FC 95% CI FC 95% CI
hsa-miR-1260a 0.55 0.43 0.71 0.96 0.93 1.00 0.98 0.94 1.01 0.95 0.89 1.01 0.86 0.69 1.07
hsa-miR-548h-5p 0.59 0.51 0.69 1.05 1.02 1.08 1.04 1.02 1.07 1.09 1.04 1.14 1.02 0.83 1.26
hsa-miR-145–5p 0.44 0.32 0.61 0.96 0.93 0.98 0.97 0.94 0.99 0.94 0.90 0.98 0.83 0.72 0.96
hsa-miR-4516 0.56 0.48 0.65 0.97 0.95 0.99 0.98 0.96 1.00 0.96 0.93 1.00 0.92 0.82 1.03
hsa-miR-331–3p 0.60 0.52 0.70 0.97 0.94 0.99 0.98 0.96 1.00 0.96 0.92 1.00 0.84 0.70 1.01
hsa-miR-181a-5p 0.62 0.53 0.72 0.99 0.97 1.02 0.99 0.97 1.02 0.99 0.95 1.03 0.81 0.70 0.92
has-miR-5010–3p 1.59 1.41 1.81 1.13 1.10 1.16 1.10 1.08 1.31 1.20 1.15 1.26 1.44 1.14 1.82
hsa-miR-374a-5p 1.72 1.40 2.13 1.03 0.99 1.07 1.03 1.00 1.06 1.05 0.99 1.11 1.09 0.89 1.34
hsa-miR-486–3p 3.35 2.59 4.33 1.15 1.10 1.21 1.12 1.07 1.16 1.23 1.14 1.32 2.20 1.66 2.91
Structure fires
hsa-miR-1260a 0.55 0.43 0.71 0.96 0.93 1.00 0.94 0.83 1.05 0.94 0.85 1.04 1.00 0.81 1.25
hsa-miR-548h-5p 0.59 0.51 0.69 1.05 1.02 1.08 1.17 1.08 1.28 1.13 1.05 1.22 1.12 0.94 1.35
hsa-miR-145–5p 0.44 0.32 0.61 0.96 0.93 0.98 0.93 0.86 1.01 0.94 0.88 1.00 0.82 0.66 1.00
hsa-miR-4516 0.56 0.48 0.65 0.97 0.95 0.99 0.94 0.89 1.00 0.95 0.90 1.00 0.90 0.77 1.06
hsa-miR-331–3p 0.60 0.52 0.70 0.97 0.94 0.99 0.94 0.87 1.01 0.95 0.89 1.01 0.83 0.70 0.99
hsa-miR-181a-5p 0.62 0.53 0.72 0.99 0.97 1.02 1.01 0.94 1.09 1.00 0.94 1.07 0.74 0.61 0.90
has-miR-5010–3p 1.59 1.41 1.81 1.13 1.10 1.16 1.35 1.24 1.48 1.30 1.20 1.39 1.37 1.07 1.77
hsa-miR-374a-5p 1.72 1.40 2.13 1.03 0.99 1.07 1.07 0.97 1.20 1.07 0.97 1.16 1.10 0.89 1.35
hsa-miR-486–3p 3.35 2.59 4.33 1.15 1.10 1.21 1.38 1.21 1.60 1.35 1.20 1.52 1.81 1.33 2.45

Associations significant after Bonferroni correction are in bolded text.

FC fold-change, CI confidence interval.

a

A priori markers were identified and originally presented in Jeong et al.[16].

b

Models also adjusted for age, BMI, ethnicity, batch effects, and Bonferroni correction. For employment duration, effect is for a 6-month increase. For fire-hours, effect is for a 10-h increase. For fire-runs, effect is for a 10-fire increase.

c

The best measure of time since most recent fire exposure (continuous log-days, split at median, split at tertiles, or split at quantiles) was selected for each miRNA by the highest Akaike information criteria (AIC) value. For time since most recent fire exposure, effect is the earliest exposure compared to later exposure(s). hsa-miR-548h-5p and hsa-miR-374a-5p used time split at the median. Hsa-miR-1260a, hsa-miR-145–5p, hsa-miR-4516, hsa-miR-331–3p, hsa-miR-181a-5p, hsa-miR-5010–5p, and hsa-miR-486–3p used time split at quantiles.