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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: J Immunol. 2021 Oct 8;207(10):2534–2544. doi: 10.4049/jimmunol.2001319

FIGURE 3.

FIGURE 3.

HCMV infection expands a population of mature cyCD3ε+ NK cells in UCB transplantation recipients, but fibroblast-adapted HCMV vaccines in healthy individuals do not. (A) Frequency of cyCD3ε+ NK cells among CD56dim umbilical cord blood NK cells are shown. (B) Representative flow cytometry demonstrating the CD16, NKG2A, CD57, and NKG2C expression among cyCD3ε+ cord blood NK cells. (C) Phenotype of total NK cells from a UCBT patient (patient 4) at indicated time points post transplantation. One representative staining of 8 UCBT patients is shown. (D) Expression of CD57 and NKG2A on cyCD3ε+ NK cells from UCBT patients with or without HCMV reactivation post-transplant. The percentages of NKG2A+CD57− (☐) or NKG2A−CD57+ (■) cells among cyCD3ε+ NK cells were evaluated. The day of HCMV reactivation post-UCBT is indicated. (E) Expression of NKG2C and cyCD3ε among CD56dim NK cells from 5 HCMV-vaccinated healthy donors at one-year post-vaccination.