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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: J Immunol. 2021 Oct 15;207(10):2445–2455. doi: 10.4049/jimmunol.2100566

Figure 2. Term maternal versus cord blood TCR-β and IgH comparison for SHM rates, CDR3 length, and gene usage.

Figure 2.

(A) Zoom-in of variable region for TCR-β and IgH. (B) V gene SHM rate in maternal vs cord blood. (C) Mean CDR3 length in maternal vs cord blood. *padj<0.05 by Wilcoxon rank-sum test and adjusted for multiple comparisons using the Benjamini-Hochberg procedure. (D) Applying hierarchical clustering to the V and J genes with significantly different usage results in perfect separation of maternal blood and cord blood samples into two clusters.