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. Author manuscript; available in PMC: 2022 Oct 14.
Published in final edited form as: Mov Disord. 2021 Oct 6;36(12):2719–2730. doi: 10.1002/mds.28815

FIG 1. ER-retention of GCase in neurons overexpressing GBA1 and in fibroblasts from patients with Gaucher disease.

FIG 1.

(A) Western blot analysis of lysates treated with Endo H, PNGase F or untreated from patient-derived dopaminergic neurons after lentiviral-mediated over expression of GBA1 for 2 weeks at multiplicity of infection (MOI) of 7.5 or 15 and control neurons treated with lentivirus expressing GFP. (B) Western blot analysis of lysates treated with Endo H, PNGase F or untreated from fibroblasts for control or patients with Gaucher disease type I (N370S/N370S) or type II (L444/L444P).