Table 4.
Logistic regression of CAC status with arginine/proline metabolism, urea cycle, and bile-acid synthesis
| Pathway | Unadjusteda |
Adjusted for Demographics |
Fully Adjusted |
|||
|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |
| Arginine/proline metabolism | 1.43 (1.06 to 1.92) | 0.02 | 1.83 (1.06 to 3.15) | 0.03 | 1.84 (1.04 to 3.27) | 0.04 |
| Urea cycle | 1.93 (1.34 to 2.80) | <0.001 | 1.58 (0.93 to 2.69) | 0.09 | 1.66 (0.94 to 2.91) | 0.08 |
| Bile-acid synthesis | 0.99 (0.82 to 1.20) | 0.92 | 1.09 (0.84 to 1.41) | 0.51 | 1.64 (0.97 to 2.75) | 0.06 |
Demographics included age, sex, and race. Full models were adjusted for demographics and statin use for arginine/proline metabolism and urea cycle pathways; for the bile-acid synthesis pathway, full models were adjusted for demographics; coronary artery disease; and use of calcium-based phosphate binder, RAAS blockade, and statin. CAC, coronary artery calcification; OR, odds ratio; RAAS, renin-angiotensin-aldosterone system.
a
Per 1 unit higher in the first principal component score of each pathway.