. Author manuscript; available in PMC: 2021 Nov 1.

Published in final edited form as: J Neural Transm (Vienna). 2021 Aug 13;128(11):1757–1765. doi: 10.1007/s00702-021-02396-y

Table 3.

Significant result from the interaction analyses of previously implicated SNPs with a cumulative pre- and perinatal adversity score in relation to lifetime tic severity

SNP	Position	Chromosome	Gene	Category	Initial sample		Replication sample
					F	P ^a	F	P ^a

rs6539267	106,785,554	12	POLR3B	GWAS TS	6.8	0.001^*	0.43	0.65

SNP single-nucleotide polymorphism, GWAS genome-wide association study, TS Tourette syndrome

Significant after correcting for multiple testing (P_all = 0.0014)

Analyses were corrected for age, sex, and socioeconomic status