Figure-2:

TF expression correlates with fibrin and PF4 expression. (A) Quantification of fibrin- and PF4-positive thrombi images from confocal immunofluorescent in COVID-19-ARDS (n=11) and non-COVID-19 ARDS (n=6) and pathologically normal control (n=11) lungs tissues using Imaris and ImageJ software. (B) Linear correlations of TF with fibrin R²=0.52; p<0.002) and TF with PF4 (R²=0.63; p=0.001). (C) Schematic diagram depicts potential mechanism by which SARS-CoV-2 infection in the lungs can increase TF expression, which might cause thrombi formation, by initiating fibrin formation and platelet activation.