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. Author manuscript; available in PMC: 2022 Aug 3.
Published in final edited form as: Pain. 2021 Oct 28;163(8):1479–1488. doi: 10.1097/j.pain.0000000000002529

Fig. 3.

Fig. 3

Paclitaxel decreases capsaicin-induced ablation of epidermal nerve fibers in the glabrous skin of the hind paw. (A) Examples of naïve hind paw skin or hind paw skin at seven days following the intraplantar injection of capsaicin (CAP) (10 μg in 20 μl vehicle) plus vehicle or capsaicin plus paclitaxel (PAC) (20 ug/10 ul) in adult transient receptor potential vanilloid 1 (TRPV1)GFP mice. Green signals represent GFP labeled by the specific antibody. Red signals represent ubiquitously expressed tdTomato. Blue signals represent DAPI. The dotted line demarcates the epidermis-dermis junction under basal epithelial cells. Arrowheads indicate counted epidermal nerve fibers. Scale bar, 50 μm. (B) Intraepidermal GFP-expressing nerve terminals were quantified. N=5 in each group (3 males and 2 females/group). ****p<0.0001 in Student’s t-test. The dotted line represents the average number of epidermal fibers in the naïve hind paw (9.6) in our previous study.