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. Author manuscript; available in PMC: 2022 Aug 3.
Published in final edited form as: Pain. 2021 Oct 28;163(8):1479–1488. doi: 10.1097/j.pain.0000000000002529

Fig. 4.

Fig. 4

Paclitaxel decreases capsaicin-induced analgesia for mechanical hyperalgesia in mice with chronic constriction injury of the infraorbital nerve (ION-CCI). Changes in mechanical sensitivity in the contralateral (A, C) or ipsilateral (B, D) side of skin behind the vibrissa pad within the infraorbital territory (V2) following a sham or ION-CCI procedure. Paclitaxel (PAC; 40 μg in 20 μl) or vehicle (Veh) alone (A, B) or a combination of capsaicin (Cap; 10 μg) and PAC or Veh (C, D) were injected 2 weeks following surgery. A-B. N=6 in Sham/PAC (3 males and 3 females) and N=5 in the other groups (3 males and 2 females). C-D. N=6 in each group (3 males and 3 females/group). Two-way repeated measures ANOVA followed by Sidak post-test; ***p<0.001 (vs. CCI/Cap/Veh).