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. Author manuscript; available in PMC: 2022 Jan 18.
Published in final edited form as: HGG Adv. 2021 Nov 6;3(1):100069. doi: 10.1016/j.xhgg.2021.100069

Figure 4. Plots of unconditional psoriasis association for the MHC and flanking regions.

Figure 4.

Each circle represents the −log(p) of association of an imputed variant, color-coded based on its membership in various categories of MHC genes, as detailed in the keys. The dashed lines denote thresholds of Bonferroni-corrected significance of 0.05. The locations of the eight HLA genes for which amino acid and protein alleles were imputed are shown at the bottom, along with colored segments denoting the boundaries of the classical MHC region (class I, II and III), the extended MHC class I (I-e) and II (II-e) regions of Horton et al. (2004), and flanking MHC regions (f). We tested association in people of three different ancestries: South Asian (A), European (B), and South Asian and European combined (C).