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. Author manuscript; available in PMC: 2022 Jan 5.
Published in final edited form as: Curr Opin Pediatr. 2022 Feb 1;34(1):53–60. doi: 10.1097/MOP.0000000000001082

Figure 1: Development of the immune-suppressive TME in solid tumors.

Figure 1:

The tumor microenvironment of pediatric solid tumors favors myeloid-mediated immune suppression. These myeloid-derived immune suppressive cells secrete factors such as transforming growth factor beta (TGFβ), prostaglandins (PGE2), arginase (ARG-1), and reactive oxygen species (ROS) that limit T cell effector function, natural killer (NK) cell activity and B cell and dendritic cell (DC) interactions limiting antigen presentation. Matrix remodeling enzymes, vascular endothelial growth factor (VEGF) and other growth factors impact vasculature and can alter the extracellular matrix. Created with BioRender.com.