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. Author manuscript; available in PMC: 2010 Jun 2.
Published in final edited form as: J Neurosci. 2009 Dec 2;29(48):15223–15231. doi: 10.1523/JNEUROSCI.3252-09.2009

Figure 2. Rate of change in healthy elderly and AD patients.

Figure 2

The left panel shows annual longitudinal atrophy in healthy elderly calculated as percentage volume change relative to baseline, while the middle panel shows longitudinal atrophy over two years. Annual change of about 0.5% can be seen across large sections of the brain surface, e.g. in temporal and prefrontal areas. The right panel shows 1 year atrophy in AD patients. The areas of change in the healthy elderly are overlapping with areas most strongly affected in Alzheimer's disease, e.g. temporal lobe cortex. However, areas that are not especially affected in AD, e.g. prefrontal cortex, also undergo large changes in healthy aging. Please note that to allow optimal visualization of regional variation, the color-scale is different for the HE and the AD groups.