Table 4.
Pearson correlations between age and 1-year volume change in healthy elderly Negative correlations between age and rate of atrophy, and positive correlations between age and rate of ventricular expansion are generally found, showing that increasing age is associated with more atrophy and increased ventricular size.
| 1 year change | |
|---|---|
| Volumetric ROIs | |
| Accumbens | −0.13 |
| Amygdala | −0.16 |
| BrainStem | −0.15 |
| Caudate | −0.06 |
| Cerebellum GM | −0.20 |
| Cerebellum WM | −0.17 |
| Cerebral WM | −0.17 |
| Hippocampus | −0.33 |
| Pallidum | −0.17 |
| Putamen | −0.14 |
| Thalamus | −0.18 |
| Ventricular ROIs | |
| Lateral ventricles | 0.08 |
| Inf lateral ventricles | 0.21 |
| 3rd ventricle | 0.03 |
| 4th ventricle | 0.08 |
| Surface ROIs | |
| Cingulate, caudal ant | −0.19 |
| Cingulate, rostral ant | −0.11 |
| Cingulate, posterior | −0.22 |
| Cingulate, isthmus | −0.25 |
| Frontal, superior | −0.13 |
| Frontal, caudal middle | −0.21 |
| Frontal, rostral middle | −0.13 |
| Frontal, pars opercularis | −0.26 |
| Frontal, pars triangularis | −0.23 |
| Frontal, pars orbitalis | −0.08 |
| Frontal, lateral orbital | −0.19 |
| Frontal, medial orbital | −0.18 |
| Frontal, pole | −0.11 |
| Parietal, precentral gyrus | −0.21 |
| Parietal, post central gyrus | −0.19 |
| Parietal, paracentral gyrus | −0.13 |
| Parietal, superior | −0.19 |
| Parietal, inferior | −0.20 |
| Parietal, supramarginal | −0.19 |
| Parietal, precuneus | −0.20 |
| Temporal, parahippocampal | −0.23 |
| Temporal, entorhinal | −0.32 |
| Temporal, pole | −0.20 |
| Temporal, superior | −0.22 |
| Temporal, middle | −0.23 |
| Temporal, inferior | −0.17 |
| Temporal, transverse | −0.30 |
| Temporal, Banks Sup Temp Sulc | −0.23 |
| Temporal, fusiform | −0.20 |
| Occipital, lateral | −0.17 |
| Occipital, pericalcarine | −0.18 |
| Occipital, lingual | −0.16 |
| Occipital, cuneus | −0.13 |
Underlined italic indicates p < .05 (r ≥ +/− .17)
Bold indicates p < .01 (r ≥ +/− .21)
Bold underlined italic indicates p < .001 (r ≥ +/− .27)