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. Author manuscript; available in PMC: 2022 Jan 5.
Published in final edited form as: Curr Opin Pediatr. 2022 Feb 1;34(1):39–47. doi: 10.1097/MOP.0000000000001088

Figure 2. Moderate depth WGS improve detection by enabling multi-omic integration from a single assay.

Figure 2.

Recent studies have demonstrated that, with advanced bioinformatic analysis, WGS to depths of 12–35x is sufficient for detection of copy number alterations, indels, translocations and fusions, assessment of chromatin accessibility and fragmentomics [51**,97**]. In addition to detecting the most common genomic alterations in childhood cancer, therefore, integration of these output also infers epigenetic and transcriptomic signatures. Combinatorial approaches, previously requiring multiple assays, enhance detection of early stage cancers. Created with BioRender.com.