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. Author manuscript; available in PMC: 2022 Dec 8.
Published in final edited form as: ACS Nano. 2021 Dec 6;15(12):20504–20516. doi: 10.1021/acsnano.1c09064

Figure 2.

Figure 2.

Hyaluronic acid-targeted nanomaterial distributes across perilesional brain tissue in CCI-injured brains. (A) Coronal brain sections from mice administered i.v. HApep-modified nanomaterial 6 hours post-CCI after 1 hour of circulation (blue, nuclei; green, HApep on nanomaterial; scale bar = 500 μm). (B) HApep-modified nanomaterial in the injured cortex stained for neurons (red, NeuN; scale bar = 500 μm). Insets show (i) perilesional cortex and (ii) hippocampus (scale bar = 100 μm). (C) Injured cortex labeled with biotinylated hyaluronic acid binding protein (magenta, bHABP; scale bar = 500 μm). Insets show (i) perilesional cortex and (ii) hippocampus (scale bar = 50 μm). Arrows note instances of nanomaterial colocalization with HABP staining.