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. Author manuscript; available in PMC: 2021 Dec 23.
Published in final edited form as: Cell Genom. 2021 Dec 8;1(3):100066. doi: 10.1016/j.xgen.2021.100066

Figure 4. Polygenic score comprised of eight common genetic variants associated with risk of liver disease.

Figure 4.

A single polygenic score for each individual was calculated by additively combining the 8 common lead genome-wide association study (GWAS) variants identified in Figure 3 via the number of liver-fat-increasing variants present in each individual, each weighted by their GWAS effect size estimate. (A) Associations between the polygenic score and incident disease occurrence after UK Biobank enrollment were assessed using a Cox proportional hazards model in 361,852 individuals who were not included in the discovery GWAS of imaging data and who did not have prevalent liver disease at time of enrollment, adjusting for age at enrollment, age at enrollment squared, sex, the first 10 principal components of genetic variation, and genotyping array. Hazard ratios (HRs) of incident disease per SD increase in the polygenic score are shown; error bars represent 95% confidence interval (CI).

(B) Rates of incident disease in each decile of the polygenic score are shown; error bars represent 95% CI.

See also Table S10.