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Frequency of pathogenic GRN mutations with CADD score>=20 in the different cohorts
| Dataset | Number of Variants | Frequency in Affected | Frequency in Unaffected |
|---|---|---|---|
| GnomAD exomes (all populations) | 127 | NA | 0.0075 |
| EFIGA families | 22 | 0.0512 | 0.0473 |
| ROSMAP | 8 | 0.014 | 0.0082 |
| NACC | 30 | 0.0052 | 0.0052 |
