Table 2:
GRN carrier status is correlated positively with tangle load and Braak stage
| Unadjusted model | Adjusted for age and sex | Adjusted for age, sex and AD status | Adjusted for age, sex and APOE ε4 dosage | |||||
|---|---|---|---|---|---|---|---|---|
| correlation coefficient | P-value | correlation coefficient | P-value | correlation coefficient | P-value | correlation coefficient | P-value | |
| global pathology * | 0.04 | 1.79E-01 | 0.03 | 3.32E-01 | 0.01 | 6.93E-01 | 0.02 | 5.21E-01 |
| Braak Stage | 0.06 | 4.10E-02 | 0.05 | 9.04E-02 | 0.04 | 1.72E-01 | 0.04 | 1.36E-01 |
| diffuse plaque burden | 0.02 | 5.43E-01 | 0.02 | 5.64E-01 | 0.00 | 9.29E-01 | 0.01 | 7.41E-01 |
| neuritic plaque burden | 0.03 | 3.27E-01 | 0.02 | 5.85E-01 | −0.01 | 8.63E-01 | 0.01 | 8.27E-01 |
| square-root of tangle density across eight brain regions | 0.08 | 8.83E-03 | 0.07 | 2.68E-02 | 0.06 | 4.93E-02 | 0.06 | 4.88E-02 |
| square-root of the overall amyloid levels | 0.03 | 3.61E-01 | 0.02 | 4.88E-01 | 0.00 | 9.86E-01 | 0.01 | 6.96E-01 |
| hippocampal sclerosis (present/absent) | −0.01 | 7.88E-01 | −0.01 | 7.31E-01 | −0.01 | 6.96E-01 | −0.01 | 6.61E-01 |
| TPD-43 pathology (present/absent) | 0.03 | 4.27E-01 | 0.02 | 4.37E-01 | 0.02 | 4.93E-01 | 0.02 | 4.82E-01 |
| presence of Lewy bodies | 0.00 | 9.60E-01 | 0.00 | 9.78E-01 | 0.00 | 9.72E-01 | 0.00 | 9.98E-01 |
| synaptic measure ** | 0.05 | 2.91E-01 | 0.06 | 2.20E-01 | 0.06 | 2.05E-01 | 0.05 | 2.47E-01 |
*
global pathology defined as global measure of pathology based on the scaled scores of pathology in 5 brain regions, where the scaled variable is the original count divided by the standard deviation
**
synaptic measure across three cortical (hippocampus, midfrontal cortex, and inferior temporal)