Table 3:
Correlation of pathological measures with rs5848 in the ROSMAP cohort
| Unadjusted model | Adjusted for age and sex | Adjusted for age, sex and AD status | Adjusted for age, sex and APOE ε4 dosage | |||||
|---|---|---|---|---|---|---|---|---|
| correlation coefficient | P-value | correlation coefficient | P-value | correlation coefficient | P-value | correlation coefficient | P-value | |
| global pathology * | −0.02 | 4.45E-01 | −0.02 | 4.84E-01 | −0.03 | 3.76E-01 | −0.03 | 3.47E-01 |
| Braak Stage | −0.03 | 3.40E-01 | −0.02 | 4.91E-01 | −0.02 | 4.14E-01 | −0.02 | 4.86E-01 |
| diffuse plaque burden | −0.01 | 6.26E-01 | −0.01 | 6.73E-01 | −0.01 | 6.56E-01 | −0.02 | 5.54E-01 |
| neuritic plaque burden | −0.01 | 6.86E-01 | −0.01 | 7.06E-01 | −0.01 | 6.57E-01 | −0.02 | 5.57E-01 |
| square-root of tangle density across eight brain regions | −0.02 | 5.22E-01 | −0.01 | 6.64E-01 | −0.02 | 5.87E-01 | −0.02 | 5.34E-01 |
| square-root of the overall amyloid levels | −0.02 | 5.78E-01 | −0.01 | 7.51E-01 | −0.01 | 6.76E-01 | −0.02 | 5.51E-01 |
| hippocampal sclerosis (present/absent), | 0.08 | 4.88E-03 | 0.09 | 3.08E-03 | 0.09 | 3.09E-03 | 0.08 | 4.55E-03 |
| TPD-43 pathology (present/absent) | 0.08 | 1.84E-02 | 0.08 | 1.00E-02 | 0.08 | 9.52E-03 | 0.08 | 1.65E-02 |
| presence of Lewy bodies | 0.00 | 8.82E-01 | 0.00 | 9.00E-01 | 0.00 | 9.08E-01 | 0.00 | 9.62E-01 |
| synaptic measure ** | 0.00 | 9.68E-01 | 0.00 | 9.76E-01 | 0.00 | 9.37E-01 | 0.00 | 9.88E-01 |
*
global pathology defined as global measure of pathology based on the scaled scores of pathology in 5 brain regions, where the scaled variable is the original count divided by the standard deviation
**
synaptic measure across three cortical (hippocampus, midfrontal cortex, and inferior temporal)