Table 4: Frequency of Hippocampal Sclerosis and TDP-43 pathology in GRN rs5848 carriers in ROSMAP.

a) Hippocampal Sclerosis (% of individuals with rs5848 within each category (AD and HS absent, AD and HS present, Healthy and HS absent, healthy and HS present), p=0.016 in 6-df chi-square test. Raw numbers are shown in (Supplementary Table S5)

b) TDP-43 Pathology (% of individuals with rs5848 within each category (AD and TDP-43 pathology absent, AD and TDP-43 pathology present, Healthy and TDP-43 pathology absent, healthy and TDP-43 pathology present), p=0.16 in 6-df chi-square test. Number of individuals in each cell is given in Supplementary Table S5.

rs5848 T alleles	Healthy at Autopsy (No AD)		Neuropathologically Confirmed AD
	HS Absent	HS Present	HS Absent	HS Present
0	0.50	0.27	0.48	0.43
1	0.41	0.46	0.44	0.42
2	0.09	0.27	0.08	0.14

rs5848 T alleles	Healthy at Autopsy (No AD)		Neuropathologically Confirmed AD
	TDP-43 Absent	TDP-43 Present	TDP-43 Absent	TDP-43 Present
0	0.53	0.43	0.50	0.47
1	0.40	0.43	0.43	0.43
2	0.07	0.14	0.07	0.10