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. Author manuscript; available in PMC: 2010 Jun 16.
Published in final edited form as: J Neurosci. 2009 Dec 16;29(50):15660–15668. doi: 10.1523/JNEUROSCI.4104-09.2009

Figure 2.

Figure 2

Lentiviral infection with APP695 rescued LTCC expression and ICa 2+ in APP−/− striatal cultures. A. Immunoblots of striatal cultures of 12 DIV from WT, littermate APP−/− and APP−/− neurons infected with APP695. Lysates were blotted for LTCC (α1C), human APP (6E10) and mouse/human APP (APPc); α-tubulin was used as loading control. B. ICa 2+ was reduced in APP−/− striatal cultures infected with APP695 (N=15) compared to APP−/− alone (N=12). Scales: 100 pA/50 msec. Data shown as mean ± SEM. C. Representative traces of whole-cell ICa 2+ recorded from APP−/− and APP−/−+APP695 neurons, respectively.