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. Author manuscript; available in PMC: 2010 Aug 10.
Published in final edited form as: J Neurosci. 2010 Feb 10;30(6):2115–2129. doi: 10.1523/JNEUROSCI.4517-09.2010

Figure 4. Decreased Theta Burst-induced LTP in area CA1 of NL1 KO Mice.

Figure 4

(A) Representative traces showing fEPSPs from a WT and a KO animal before (“1”) and after (“2”) LTP induction by TBS. (B) Time course of fEPSPs before and after LTP induction by TBS in WT (n=6) and KO (n=6) animals. The time points of the representative traces in (A) are noted on the graph (see “1” and “2”). (C) Synaptic strength is unchanged in NL1 KO mice. Representative traces from a WT and a KO animal show input-output measurements with increasing stimulus intensities. Responses were measured in area CA1 of mouse hippocampus. (D) Average fEPSP slope plotted against fiber-volley amplitude. Input-output measurements were performed in wild-type (n=6) and KO (n=5) animals. (E) Overlayed representative traces from a WT and a KO animal showing paired-pulse facilitation of excitatory synaptic responses at interstimulus intervals ranging from 30-600 ms. (F) Average paired-pulse facilitation of excitatory synaptic responses did not show any difference between WT (n=12) and KO (n=8) animals. Data plotted as means +/− SEM.