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. Author manuscript; available in PMC: 2010 Aug 10.
Published in final edited form as: J Neurosci. 2010 Feb 10;30(6):2115–2129. doi: 10.1523/JNEUROSCI.4517-09.2010

Figure 7. NL1 KO Mice Exhibit a Decreased NMDA/AMPA Ratio in the Dorsal Striatum Accompanied by Increased Repetitive Behavior that can be Rescued Pharmacologically.

Figure 7

(A) NMDAR and AMPAR mediated responses are indicated in wild-type traces. Current amplitude was normalized to that of the AMPAR peak. Amplitude of NMDAR currents at +40 mV was measured in a 2 ms window set at 50 ms from spike onset (dashed line on traces). (B) The time spent grooming was observed 30 min after systemic administration of the NMDA partial co-agonist D-cycloserine (DCS; 20 mg/kg). Administration of DCS rescued the increased grooming phenotype in NL1 KO mice [*p<0.02 compared to all other groups, Post-hoc Tukey HSD test; 3-way ANOVA; sex (between-subjects factor): p=0.45; genotype (between-subjects factor): p<0.004; treatment (between-subjects factor): p<0.02; sex × genotype interaction: p=0.48; sex × treatment: p=0.54; genotype × treatment interaction: p=0.09; sex × genotype × treatment interaction: p=0.36]. Vehicle: N = 20 littermate pairs, DCS: N = 19 littermate pairs. Data represent means +/− SEM.