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. Author manuscript; available in PMC: 2010 Aug 10.
Published in final edited form as: J Neurosci. 2010 Feb 10;30(6):2150–2159. doi: 10.1523/JNEUROSCI.4818-09.2010

Figure 6. Neurons' relative synchrony dependence changes with background conductance input.

Figure 6

A. a) In a model neuron stimulated with constant excitatory conductance and randomly varying inhibitory conductance, spike responses are only weakly dependent on input synchrony, compared to input mean. b) Proportionately increasing the model neuron's inhibitory and excitatory conductance inputs causes its output to become synchrony dependent.

B. In a layer 5 bursting neuron, changing the synchrony of the current stimulus has little effect on spike output.

C. Driving the same neuron in B with stronger artificial synaptic drive (i.e. proportionately scaling up the mean inhibitory and excitatory conductances) creates synchrony dependence in the cell's spike output.

D. a) In n = 6 large bursting pyramidal neurons, adding artificial synaptic drive changed their response profiles from relatively synchrony-independent to relatively synchrony-dependent. b) In n = 13 neurons, including G42, GIN, L2/3, and L5R neurons, scaling up the excitatory and inhibitory conductances that the neuron received increased its synchrony dependence, whether or not the neuron's response was initially synchrony dependent. Neurons are color- and marker- coded as in Figures 3, 4, and 5.