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. Author manuscript; available in PMC: 2022 Jan 25.
Published in final edited form as: Commun Med (Lond). 2021 Dec 9;1:60. doi: 10.1038/s43856-021-00060-w

Fig. 4. TDP-43 induces HERV-K transcription.

Fig. 4.

(A) HERV-K and HERV-W env levels in SH-SY5Y neuronal cells (n = 6 biological replicates). (B) Expression of TDP-43 in SH-SY5Y neuronal cells transfected with the human wild type TARDBP cDNA (TDP-43) (n = 5 biological replicates) or empty vector plasmid control (mock) (n = 6 biological replicates). (C) Analysis of impact of TDP-43 on HERV-K env transcription in TDP-43 cells (n = 5 biological replicates) and mock cells (n = 6 biological replicates). (D) Analysis of impact of TDP-43 on HERV-W env transcription in TDP-43 cells (n = 5 biological replicates) and mock cells (n = 6 biological replicates). Boxplot data represent median with min and max as whiskers. *P < 0.05, **P < 0.005. (E) Correlation analysis of TDP-43 to HERV-K and HERV-W env transcription (n = 11 individual samples).