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. Author manuscript; available in PMC: 2022 May 16.
Published in final edited form as: Sci Transl Med. 2022 Feb 2;14(630):eabm3302. doi: 10.1126/scitranslmed.abm3302

Fig. 7. Low-dose mRNA vaccine confers protection against lung pathology against most tested strains of SARS-CoV-2 in K18-hACE2 transgenic mice.

Fig. 7.

Seven to nine-week-old female K18-hACE2 transgenic mice were immunized, boosted with 0.25 μg of mRNA vaccines, and challenged with WA1/2020, WA1/2020 N501Y/D614G, B.1.1.7/E484K, B.1.351, or B.1.617.2. as described in Fig. 5. Hematoxylin and eosin staining of lung sections harvested at 6 dpi or from an uninfected animal are shown. Images show low- (top; scale bars, 1 mm), medium- (middle; scale bars, 250 μm), and high-power (bottom; scale bars, 100 μm). Representative images of multiple lung sections are presented from n = 2 per group.