. Author manuscript; available in PMC: 2022 Apr 27.
Published in final edited form as: Nat Genet. 2022 Mar 31;54(4):437–449. doi: 10.1038/s41588-022-01016-z
Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms