Table 4.

Survival analyses predicting time to incident cognitive impairment (CDR ≥0) among participants cognitively normal at baseline.

	Cox Proportional Hazards Model			Fine and Gray Model
	HR	95% CI	p	HR	95% CI	p
Race/Ethnicity
Ref: nHW	—	—		—	—
AA	0.86	0.74, 0.99	0.038	0.85	0.73, 0.97	0.020
Hispanic	1.46	1.19, 1.80	<0.001	1.47	1.21, 1.78	<0.001
Asian	1.34	0.97, 1.85	0.080	1.40	1.03, 1.90	0.032
Depression and Antidepressant Use
Ref: Depression − Antidepressant −	—	—		—	—
Depression − Antidepressant +	1.31	1.13, 1.53	<0.001	1.26	1.09, 1.45	0.002
Depression + Antidepressant −	1.77	1.41, 2.23	<0.001	1.73	1.37, 2.17	<0.001
Depression + Antidepressant +	1.45	1.18, 1.80	<0.001	1.40	1.15, 1.71	<0.001
Gender
Ref: Male	—	—		—	—
Female	0.82	0.75, 0.90	<0.001	0.86	0.78, 0.94	<0.001
Age at Baseline	1.07	1.06, 1.08	<0.001	1.05	1.05, 1.06	<0.001
Education	0.97	0.96, 0.99	0.001	0.98	0.96, 0.99	0.007
APOE ε4+	1.52	1.38, 1.67	<0.001	1.49	1.36, 1.63	<0.001

Abbreviations: CDR=Clinical Dementia Rating; HR=Hazard Ratio; CI=Confidence Interval; Ref=Reference category; nHW=non-Hispanic White; AA=African American; AIAN= American Indian and Alaskan Natives; APOE ε+= Apolipoprotein ε4 allele