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Mouse model with MC38 colon cancer syngeneic tumor implanted into the subcutaneous tissue or subcutaneous and liver as depicted in Lee JC and colleagues (54). In liver and subcutaneous tumor-bearing mice, there are reduced PD-1hi/CTLA-4hi CD8+ T cells, and these tumors have reduced response to PD-1 blockade. Figure created with BioRender.com.
