Table 1.
Cre-driver and -reporter mice.
| Strain | References | Source Information | Key Gene |
|---|---|---|---|
| Atoh1-Cre | Matei et al. Dev Dyn 234(3):633–50. 2005. | Bernd Fritzsch, University of Iowa Jax 011104 https://www.jax.org/strain/011104 |
Transgenic construct containing the JQ2-Atoh1 promoter fragment ligated to the bacteriophage P1 Cre recombinase |
| Lmx1a-Cre | Victor V. Chizhikov, Anne G. Lindgren, D. Spencer Currle, Matthew F. Rose, Edwin S. Monuki, Kathleen J. Millen Development 2006 133: 2793–2804; doi: 10.1242/dev.02441 | Victor V. Chizhikov, University of Tennessee HSC http://www.informatics.jax.org/allele/key/569853 |
BAC transgenic construct containing ~200 kb of the mouse Lmx1a locus with Lmx1a coding sequence replaced by Cre coding sequence |
| Vglut2-IRES-Cre (Slc17a6-IRES-Cre) | Vong, Linh, et al. “Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons.” Neuron 71.1 (2011): 142–154. | Jax 016963 https://www.jax.org/strain/016963 |
IRES-Cre inserted downstream of the stop codon of Slc17a6 on chromosome 7 |
| Vgat-IRES-Cre (Slc32a1-IRES-Cre) | Vong L, Ye C, Yang Z, Choi B, Chua S, Lowell BB. Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron. 2011; 71:142–154 | Jax 028892 https://www.jax.org/strain/028862 |
IRES-Cre inserted after the Slc32a1 stop codon |
| Ai9(R26-lsl-tdTomato) | Madisen L; Zwingman TA; Sunkin SM; Oh SW; Zariwala HA; Gu H; Ng LL; Palmiter RD; Hawrylycz MJ; Jones AR; Lein ES; Zeng H. 2010. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci 13(1):133–40 | Jax 007909 https://www.jax.org/strain/007909 |
tdTomato (red fluorescent protein) insertion after lox-STOP-lox at Rosa26 locus |
| Ai14(R26-lsl-tdTomato) reporter | Madisen L; Zwingman TA; Sunkin SM; Oh SW; Zariwala HA; Gu H; Ng LL; Palmiter RD; Hawrylycz MJ; Jones AR; Lein ES; Zeng H. 2010. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci 13(1):133–40 | Jax007914 https://www.jax.org/strain/007914 |
Rosa-CAG-LSL-tdTomato- WPRE targeting vector inserted between exon 1 and 2 of the Gt(ROSA)26Sor locus |
| R26-LSL-L10GFP reporter | Krashes, Michael J., et al. “An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger.” Nature 507.7491 (2014): 238. | Available from originating investigators http://www.informatics.jax.org/allele/MGI:5559562 |
Floxed transcription STOP cassette followed by EGFP/Rpl10 fusion reporter gene under control of the CAG promoter targeted to the Gt(ROSA)26Sor locus |
| Pdyn-IRES-Cre | Krashes, Michael J., et al. “An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger.” Nature 507.7491 (2014): 238. | Jax 027958 https://www.jax.org/strain/027958 |
IRES-Cre inserted downstream of the endogenous Pdyn (prodynorphin) gene |
| Calca-Cre (Calca-tm1.1-Cre-EGFP) | Carter, M., Soden, M., Zweifel, L. et al. “Genetic identification of a neural circuit that suppresses appetite.” Nature 503, 111–114 (2013). | Richard Palmiter, University of Washington (shared by Andrew Russo, University of Iowa) | Cre:GFP inserted downstream of the endogenous CGRP (calcitonin-gene-related-peptide) gene |