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. Author manuscript; available in PMC: 2022 May 17.
Published in final edited form as: Small. 2022 Feb 7;18(12):e2107832. doi: 10.1002/smll.202107832

Figure 5. Comparison of plasmonic LAMP and a commercially available colorimetric LAMP kit for SARS-CoV-2 RNA detection.

Figure 5.

(A) Photograph of colorimetric LAMP reaction with different RNA inputs and incubation time at 65 °C. Red box highlights the visually detectable sample. RSV RNA (50 copies/μL) was used as a negative control. (B) Detection results of plasmonic LAMP with different LAMP incubation times. At indicated times, LAMP products were processed for plasmonic sensing using Au-Ag-shells-based probes. Dashed line marks the background (3 times standard deviation above mean of zero indicator). Blue and green arrows indicate the detection limits for 15 min and 45 min, respectively. (C) Gel image of positive and negative controls obtained by colorimetric LAMP (blue) and plasmonic LAMP (red). The symbols (−) and (+) indicate 0 and 50 SARS-CoV-2 RNA copies/μL inputs, respectively. Both reactions were conducted at 65 °C for 45 min.