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. Author manuscript; available in PMC: 2022 Apr 12.
Published in final edited form as: Cancer Res. 2022 Apr 1;82(7):1234–1250. doi: 10.1158/0008-5472.CAN-21-1168

Figure 8.

Figure 8.

TFEB provokes metabolic anergy in MYC-induced B cell lymphoma. A-G, Differential and statistically significant metabolites and genes (p ≤ 0.1 and p ≤ 0.05, respectively), were grouped based on the indicated KEGG metabolic pathways, and are illustrated as two-axis dot plots to show the metabolite abundance (left-axis of plots) and changes in mRNA expression (right-axis of plots) that are up-regulated or down-regulated following the induction of TFEB activity in Eμ-Myc lymphoma cells. H, Untargeted metabolomic profiling via LC-MS/MS was performed in Eμ-Myc lymphoma expressing vector or TFEBSA-ERT2 after treatment with vehicle or 4-OHT for 4 days (n = 4). LC-MS spectra was analyzed using MZMine2. These data were then uploaded into MetaboAnalyst, and samples were normalized by the sum of all metabolites and log2 transformed, followed by a functional enrichment analysis to assess metabolic pathway enrichment using MetaboAnalyst. I, Normalized log2 transformed metabolomic data from Eμ-Myc lymphoma expressing TFEBSA-ERT2 treated with vehicle or 4-OHT were uploaded to GeneGo MetaCore to assess metabolic pathways affected by TFEB activation.