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. Author manuscript; available in PMC: 2022 May 28.
Published in final edited form as: Mol Psychiatry. 2022 Apr 5;27(5):2439–2447. doi: 10.1038/s41380-022-01500-2

Figure 1. Associations between genetic burden and cognitive measures in SCZ cases and controls.

Figure 1.

Genetic profiles include: (1) polygenetic risk scores (PRS) for schizophrenia (SCZ), intelligence quotient (IQ) and educational attainment (EDU); (2) size of copy number variants (CNV) deletions in KB; and (3) rare exonic burden, measured as number of disruptive and damaging ultra-rare variants in constrained genes. Burden measures were standardized. Cognitive measures include Educational attainment (EDU) and premorbid cognitive ability (measured by intelligence quotient (IQ) scores, IQ). EDU is Z-score standardized by birth year and sex. Premorbid cognitive ability is Z-score standardized by birth year. The analysis used linear regression models including all genetic burdens above and adjusted for the first 5 ancestry principle components and genotyping waves. Beta coefficient and 95% confidence intervals (CI) are reported. Estimates past significance threshold (corrected for 20 tests, P<0.0025) are marked in solid circle. Asterisk indicates significant difference between SCZ cases and controls. The data for this figure are in Table S3.