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Assessment of PICCO macrocyclization. (A) Beads displaying a linker capped with Cys-STmp and an oxazole (Compound 1a) were subjected to three rounds of amination and acylation to generate a linear PICCO (Compound 2). Cysteine deprotection allows thioether formation, generating the macrocycle (Compound 3). (B) LC/MS analysis demonstrates complete cyclization of the linear precursor. See supporting information (Fig. S2) for complete characterization.
