Table 3.

Main and stratified associations for marginal zone lymphoma (MZL) risk by autoimmune condition and MZL polygenic risk score (PRS) in participating InterLymph Consortium studies.

Autoimmune Conditions	MZL PRS	Controls	MZL	OR	95% CI	p-interaction*
None		2774	376	1.00	ref
Any		109	31	1.97	(1.33–2.94)	NA
No B-cell conditions		2764	373	1.00	ref
B-cell conditions		28	24	5.88	(3.55–9.74)	NA
No multiple organs		2770	374	1.00	ref
Multiple organs		33	24	4.96	(3.04–8.12)	NA
None/Any	Tertile 1	2123	294	1.00	ref
	Tertile 2	586	86	1.10	0.84–1.43
	Tertile 3	174	27	1.09	0.71–1.68	NA
None	Tertile 1	2046	272	1.00	ref
	Tertile 2	567	80	1.10	0.83–1.44
	Tertile 3	161	24	1.10	0.70–1.74
Any	Tertile 1	77	22	2.13	1.28–3.55
	Tertile 2	19	6	2.64	1.02–6.83	p-interaction = 0.58
	Tertile 3	13	3	1.42	0.39–5.10
No B-cell	Tertile 1	2037	272	1.00	ref
Conditions	Tertile 2	566	78	1.06	0.81–1.40
	Tertile 3	161	23	1.48	0.66–1.67
B-cell	Tertile 1	16	17	7.95	3.79–16.7
conditions	Tertile 2	7	5	6.07	1.80–20.5	p-interaction = 0.21
	Tertile 3	5	2	2.59	0.48–13.9
No multiple organs	Tertile 1	2042	272	1.00	ref
	Tertile 2	567	79	1.08	0.82–1.42
	Tertile 3	161	23	1.05	0.66–1.67
Multiple organs	Tertile 1	19	18	7.43	3.74–14.8
	Tertile 2	9	4	4.90	1.44–16.7	p-interaction =0.27
	Tertile 3	5	2	3.24	0.60–17.5
No organ-specific conditions	Tertile 1	2040	268	1.00	ref
	Tertile 2	566	77	1.06	0.80–1.40
	Tertile 3	161	24	1.11	0.70–1.75
Organ-specific conditions	Tertile 1	60	5	0.59	0.23–1.51
	Tertile 2	11	2	1.26	0.27–5.88	p-interaction =0.80
	Tertile 3	8	1	0.65	0.08–5.27

^*Wald test for homogeneity