Skip to main content
. Author manuscript; available in PMC: 2023 Jan 19.
Published in final edited form as: Stem Cells. 2022 Mar 3;40(1):14–21. doi: 10.1093/stmcls/sxab007

Figure 1. Regulation of hematopoiesis by microbes.

Figure 1.

(A) Left panel: Microbial components and metabolites derived from commensal microbes in the healthy gut maintain balanced hematopoiesis in the steady-state. Middle panel: During infection, invading pathogens and their components induce myeloid-biased hematopoiesis (emergency myelopoiesis). Right panel: Myeloid-biased hematopoiesis during aging and under stress conditions such as obesity and type II diabetes may be a consequence of commensal microbial dysbiosis and intestinal permeability, which results in elevated levels of microbes and microbiome-derived components in the circulation.