Table 1.
Characteristics of patients with NASH used as stool donors for germ-free mice
| Variables | NASH | |
|---|---|---|
| Patient 1 | Patient 2 | |
| Demographics | ||
| Gender | Female | Female |
| Body mass index, kg/m2 | 31.6 | 30.9 |
| Type 2 diabetes | Yes | No |
| Arterial hypertension | Yes | Yes |
| Metabolic syndrome | Yes | Yes |
| Waist circumference (cm) | 115 | 100 |
| Laboratory parameters | ||
| Albumin, g/dL | 4.0 | 4.2 |
| Creatinine, mg/dL | 1.28 | 1.03 |
| Urea, mg/dL | 39 | 31 |
| Uric acid, mg/dL | 8.4 | 7.8 |
| AST, U/L | 83 | 38 |
| ALT, U/L | 78 | 43 |
| GGT, U/L | 334 | 86 |
| Alkaline phosphatase, U/L | 98 | 103 |
| Bilirubin, mg/dL | 0.4 | 0.4 |
| Ferritin, μg/L | 94 | 93 |
| Triglycerides, mg/dL | 384 | 231 |
| Total cholesterol, mg/dL | 206 | 251 |
| HDL cholesterol mg/dL | 33 | 38 |
| LDL cholesterol mg/dL | 114 | 156 |
| Platelet count, x109/L | 319 | 261 |
| INR | 2.4 | 0.9 |
| Liver histology features & | ||
| NAFLD Activity Score | 5 | 7 |
| Steatosis grade | 1 | 3 |
| Ballooning | 2 | 2 |
| Inflammation grade | 2 | 2 |
| Fibrosis stage | 3 | 2 |
&,
per NASH clinical research network histologic scoring system [29].
ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, gamma-glutamyl transferase; HDL, high-density lipoprotein; INR, international normalized ratio; LDL, low-density lipoprotein; NAFLD, non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis.