Using a 24-hour retention interval, APP and A7KO-APP exhibit a novel object recognition deficit compared to WT and A7KO. WT and A7KO mice showed a preference for the novel object following a 24-hour delay between identical object exploration during training and the introduction of a novel object during the test phase. One sample two-tailed t- test against a theoretical mean of 0.5000 yielded p values of 0.003 and 0.018, respectively for WT and A7KO, respectively. APP and A7KO-APP mice did not exhibit any preference for object exploration (p=0.671 and 0.145, APP and A7KO-APP, respectively). *indicates significant difference from theoretical mean of 0.50.