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. Author manuscript; available in PMC: 2022 Oct 14.
Published in final edited form as: Glia. 2022 Apr 4;70(7):1337–1358. doi: 10.1002/glia.24177

Figure 6. Phagocytosis is upregulated in SMA iPSC derived microglia compared to control.

Figure 6.

A. Phagocytosis was analyzed by flow cytometry. (n=6) *** p=0.002. Gene expression analysis of B. C1qa, C. C3, and D. TREM2 were determined by qRT-PRC. (control n=5, SMA n=5) ** p=0.0058, *** p=0.0008 E. TREM2 was knocked down using siRNA (control n=3, SMA n=3) and gene knockdown validated by qRT-PCR. F. Phagocytosis of TREM2 knockdown (control n=3, SMA n=3) was analyzed by flow cytometry. *p=0.0443, ** p=0.0073, *** p=0.0005. All groups were analyzed by one-way ANOVA followed by post hoc Tukey’s test for multiple comparisons. Values represent mean ±SEM.