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. Author manuscript; available in PMC: 2022 Dec 6.
Published in final edited form as: Cancer Res. 2022 Jun 6;82(11):2047–2056. doi: 10.1158/0008-5472.CAN-21-3503

Figure 1. Innate immune signaling pathways.

Figure 1.

TNF binding to TNFR1 triggers the assembly of LUBAC ssscomplex, and the activation of TAK1 and subsequently IKK. TLR4 or IL-1R1 triggers the interaction of the MyD88-IRAK complex which engages TRAF6. Activated TLR4 can also be endocytosed and signal via RIPK1. RIG1 binding to dsRNA promotes its association to MAVS complex which converges on TRAF6. MAVS also interacts with TRAF3, TBK1, and STING to activate IRF3 and IRF7. NLRP3 triggers secretion of IL-1b and IL-18.