Figure 6.

Decoy vesicles confer widespread inhibition of emerging SARS-CoV-2 Spike variants. Left: Dose-response curves depicting the inhibition of various strains of SARS-CoV-2 Spike pseudotyped lentivirus (Spike-Lenti) by WT-ACE2 UC-EVs. The parental strain is the D614G Spike-lenti. Curves are normalized to the percent of cells transduced at the lowest EV dose in a particular curve. Symbols repesent the mean of three biological replicates; error bars are standard error of the mean. Data are representative of two independent experiments. Right: Log(ID₅₀) values calculated from the dose response curves. Numbers above each point report the relative resistance for a given strain relative to the parental strain (D614G). Error bars represent 99% confidence intervals for the parameter (ID₅₀) estimation.