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Effects of pH, salt and serum on anti-Staphylococcal activity of YZ105 and antibiotics
| Compound | pH 7.4 |
pH 8 | pH 6.8 |
pH 5.5 | 100 mM NaCl |
1% Serum |
5% Serum |
10% Serum |
|---|---|---|---|---|---|---|---|---|
| YZ105 | 1-2 | <0.5 | 2 | 4-8 | 2 | 2 | 8 | 8-16 |
| Nafcillin | 0.5-1 | 1 | 1 | 0.5 | 1-2 | 1 | 2-4 | 4 |
| Linezolid | 4 | 4-8 | 4 | 4 | 4 | 4 | 8 | 8 |
