Representative cases of tumor vasculature images using different imaging
methods Regular Color Doppler (1st row row), overlay HDMI on B-mode
(2nd row), and the HDMI of the breast mass (3rd row).
The representative new and initial biomarkers are shown at the left side for
each HDMI image (3rd row). The two columns on the left represent two malignant
breast masses (M1 and M2), and the two columns on the right represent benign
breast lesions (B1 and B2). The histological results for both malignant cases
(M1 and M2) are reported as invasive mammary carcinoma with mixed ductal and
lobular features, Grade III, and invasive ductal carcinoma Grade III,
respectively. The biopsy results for the benign cases (B1 and B2) are indicated
as benign fibroadenoma. The reference clinical Doppler images shown on row 1,
were acquired in a clinical setting by a different sonographer using a clinical
ultrasound scanner different from the research ultrasound platform used by the
investigative team.