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. Author manuscript; available in PMC: 2022 Nov 18.
Published in final edited form as: Eur Radiol. 2022 Apr 29;32(11):7448–7462. doi: 10.1007/s00330-022-08815-2

Figure 2.

Figure 2.

Representative cases of tumor vasculature images using different imaging methods Regular Color Doppler (1st row row), overlay HDMI on B-mode (2nd row), and the HDMI of the breast mass (3rd row). The representative new and initial biomarkers are shown at the left side for each HDMI image (3rd row). The two columns on the left represent two malignant breast masses (M1 and M2), and the two columns on the right represent benign breast lesions (B1 and B2). The histological results for both malignant cases (M1 and M2) are reported as invasive mammary carcinoma with mixed ductal and lobular features, Grade III, and invasive ductal carcinoma Grade III, respectively. The biopsy results for the benign cases (B1 and B2) are indicated as benign fibroadenoma. The reference clinical Doppler images shown on row 1, were acquired in a clinical setting by a different sonographer using a clinical ultrasound scanner different from the research ultrasound platform used by the investigative team.