Table 4.
Diagnostic performance of HDMI biomarkers for predicting the status of ER, PR, HER2, Ki-67 and molecular subtypes in malignant masses.
| Immunohistochemical biomarkers |
BAmean |
ap value |
FD | ap value | NV |
ap value |
NB |
ap value |
|---|---|---|---|---|---|---|---|---|
| ER | 0.141 | 0.259 | 0.950 | 0.908 | ||||
| Negative (25) | 68.3±45.2 | 1.2±0.3 | 13.6±12.3 | 6.2±5.8 | ||||
| Positive (159) | 80.6±44.1 | 1.1±0.2 | 14.0±14.6 | 6.6±7.9 | ||||
| PR | 0.711 | 0.020 | 0.019 | 0.026 | ||||
| Negative (38) | 80.6±40.7 | 1.2±0.3 | 18.6±14.9 | 8.6±7.8 | ||||
| Positive (146) | 78.5±45.4 | 1.1±0.2 | 12.7±14.0 | 6.0±7.6 | ||||
| HER2 | 0.393 | 0.036 | 0.004 | 0.016 | ||||
| Negative (159) | 77.1±40.1 | 1.1±0.2 | 12.6±13.6 | 5.9±7.3 | ||||
| Positive (25) | 90.6±30.1 | 1.2±0.2 | 22.4±16.3 | 10.4±9.2 | ||||
| Ki-67 | 0.209 | 0.036 | 0.001 | 0.004 | ||||
| <0.14 (113) | 75.7±46.0 | 1.2±0.2 | 12.4±14.2 | 5.8±7.4 | ||||
| ≥0.14 (71) | 84.1±41.4 | 1.1±0.3 | 16.4±14.2 | 7.7±8.0 | ||||
| Subtypes | 0.047 | 0.776 | 0.018 | 0.050 | ||||
| Luminal A (77) | 74.3±47.5 | 1.1±0.2 | 11.2±14.1 | 5.3±7.5 | ||||
| Luminal B (HER2+) (61) | 84.5±44.2 | 1.1±0.2 | 14.3±13.3 | 6.7±7.4 | ||||
| Luminal B (HER2−) (21) | 92.4±24.7 | 1.2±0.3 | 23.7±16.6 | 11.1±9.6 | ||||
| HER2+ (4) | 81.1±54.8 | 1.2±0.2 | 15.8±14.5 | 7.3±6.4 | ||||
| TN (21) | 65.8±44.3 | 1.2±0.3 | 13.2±12.2 | 5.9±5.9 |
Number in parentheses are lesion numbers.
a
A p value smaller than 0.05 indicates significance.