Figure 7.

Inhibition of human I_CatSper by compounds from each hit series. A. Representative I_CatSper recording from human sperm in cesium divalent free media (CsDVF) elicited by the voltage ramp in the absence (black) and presence (purple) of test compound 2a. Baseline signal in high saline (HS) buffer shown in grey. B. Current density plots of tested compounds showing inhibition of I_CatSper at +80 mV (positive scale) or −80 mV (negative scale). Data are displayed as means ± SEM of at least 3 independent experiments.