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Quinolone hit series 3 SAR determined in the human sperm calcium influx assay
|
|||
|---|---|---|---|
| Compound | R1 | R2 | IC50, μM |
| 3a | Me |
|
3.6 ± 0.6 |
| 3b | H |
|
15 ± 2 |
| 3c | Me |
|
10.7 ± 0.3 |
| 3d | Me | H | 96 ± 9 |
| 3e | Me |
|
> 100 |
| 3f | H |
|
> 100 |
| 3g |
|
> 100 | |
CatSper activated by 3 μM progesterone. IC50 values are means ± SEM of 3 independent experiments.
