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. Author manuscript; available in PMC: 2022 Oct 14.
Published in final edited form as: ChemMedChem. 2022 Jun 14;17(15):e202000499. doi: 10.1002/cmdc.202000499

Table 7.

Triazolopyridazine hit series 7 SAR determined in the human sperm calcium influx assay

graphic file with name nihms-1812278-t0060.jpg
Compound R1 R2 IC50, μM
7a m-Me graphic file with name nihms-1812278-t0061.jpg 20 ± 1
7b m-Me graphic file with name nihms-1812278-t0062.jpg > 100
7c m-Me graphic file with name nihms-1812278-t0063.jpg 58 ± 5
7d p-Me graphic file with name nihms-1812278-t0064.jpg 25 ± 3
7e p-Me graphic file with name nihms-1812278-t0065.jpg 21.7 ± 0.4
7f p-Me graphic file with name nihms-1812278-t0066.jpg 68 ± 6
7g m-Me graphic file with name nihms-1812278-t0067.jpg 35 ± 10

CatSper activated by 3 μM progesterone. IC50 values are means ± SEM of 3 independent experiments.