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. Author manuscript; available in PMC: 2022 Oct 14.
Published in final edited form as: Diabetes Obes Metab. 2022 Jun 15;24(9):1829–1839. doi: 10.1111/dom.14769

TABLE 2.

Summary of multivariate mediation analyses of hospitalization for heart failure and composite kidney outcome using forward selection approaches

Time Point HHF Composite kidney outcome
Mediator (by adding factors sequentially by larger percent mediation) % mediation (95% CI) Mediator (by adding factors sequentially by larger percent mediation) % mediation (95% CI)
Early change ALB, CL, HCT, HDL-C, log (UACR), urate, protein 83 (22.81, 303.30) HbA1c, HCT, urate 118 (47.43, 405.81)
Weighted average change ALB, urate, haemoglobin 110 (43.48, 378.78) Haemoglobin, urate 121 (51.49, 422.62)

ALB, albumin; CL, chloride; HbA1c, glycated haemoglobin; HCT, haematocrit; HDL-C, high-density lipoprotein cholesterol; HHF, hospitalization for heart failure; UACR, urine albumin-to-creatinine ratio.