RF-pulse simulation and phantom measurement. A–C, The simulated RF-pulse profiles of the 2π-CSAP (used as inversion pulse in the simulation for simplicity). D–F, The corresponding brain metabolite phantom measurements. G, The noise-like water map, which emphasizes a superior homogeneous overall water suppression compared to (I). The two-creatine (H-I) and water reference (J) maps agree with each other, while (L-N) show clearly different patterns. This proves that the proposed 2π-CSAP guarantee a uniform refocusing in both the selected chemical shift dimension as well as in the complete excited spatial volume. The measurements were performed with TE = 82 ms, TR = 1500 ms, matrix = 65 × 20 × 8 (4.3 × 11 × 13.8 mm), and measurement time = 3 min