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The red proteins are known PPM1D targets. The red inhibitory symbol denotes the inactivation of that protein upon PPM1D dephosphorylation. The green arrow represents activation of the protein upon dephosphorylation. A) PPM1D inhibits key players involved in double-stranded break repair resulting in decreased NHEJ and increased HR. B) PPM1D inhibits several BER and NER repair proteins leading to decreased single-stranded break repair.
